Wilms Tumor Ppt New !exclusive!

| Feature | COG (North America) | SIOP (Europe & most of world) | |--------|---------------------|-------------------------------| | Initial step | Immediate nephrectomy | Preoperative chemotherapy (4 weeks) | | Stage definition | Based on surgical/pathologic findings | Based on imaging response & post-chemo histology | | Advantage | Precise surgical staging | Reduced rupture rate, lower stage distribution | | Disadvantage | Higher surgical complications | Risk of treating non-Wilms tumors (very low) |

| Risk Group | Criteria | Treatment | |------------|----------|------------| | | Stage I favorable histology, age <2y, tumor weight <550g | Nephrectomy only (no chemo) | | Standard | Most stage I-III favorable histology, no adverse molecular markers | Vincristine + actinomycin ± doxorubicin | | High | Diffuse anaplasia, stage IV favorable with blastemal type, TP53 mutation, 1q gain | Intensified chemo (regimen M) + radiation + consider experimental | wilms tumor ppt new

New COG/SIOP harmonized risk groups (AREN0534, UMBRELLA): | Feature | COG (North America) | SIOP

Subtitle: A Modern Slide Deck for Pediatric Oncology, Nephrology, and Radiology Teams Introduction: Why a “New” Wilms Tumor PPT? Wilms tumor (nephroblastoma) is the most common primary renal malignancy in children. While the cure rate exceeds 90% for low-risk disease, the landscape of its management is rapidly evolving. The old PowerPoints focused solely on histology (favorable vs. anaplastic) are obsolete. The old PowerPoints focused solely on histology (favorable