using pharmacokinetic modeling (often a 1- or 2-compartment model).
using the formula above. Multiply cumulated activity (Ā) by the S-value to obtain dose in Gy. mird237
Researchers are now integrating MIRD237 S-values into that predict dose from a single time-point scan. For example, a U-Net architecture trained on thousands of MIRD237 phantom simulations can estimate kidney dose from a single Lu-177 SPECT/CT acquired at 24 hours post-injection. using pharmacokinetic modeling (often a 1- or 2-compartment
For decades, MIRD pamphlets (No. 1 through No. 22) focused on —standardized geometric representations of the human body. But as therapy moved from diagnostic doses to high-activity treatments (e.g., Y-90 microspheres for liver cancer, Lu-177 DOTATATE for neuroendocrine tumors), clinicians needed cellular and subcellular resolution. Y-90 microspheres for liver cancer